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pentobarbital will reduce the level or result of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital decreases amounts of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration with strong CYP3A4 inducers; these drugs decrease publici